<span style="font-weight: 400;">Fresh embryo transfers were the only option when in vitro fertilization (IVF) was initially introduced due to the limited progress in cryopreservation techniques. However, over the past four decades, significant advancements in cryopreservation, culture media, and reproductive technologies have made both fresh and frozen embryo transfers (FETs) widely practiced. Nowadays, FETs are generally preferred, depending on the age of the couple, number of oocytes retrieved, quality of embryos, adequacy of the endometrial lining, and hormonal parameters.</span>

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<h3 style="width: 100%;"><b>Fresh and frozen embryo transfers: Understanding the differences</b></h3>
<b>Fresh embryo transfers:</b>

<span style="font-weight: 400;">A fresh embryo transfer is typically scheduled 5 days after the eggs are collected from the patient. In the laboratory, the eggs are fertilized with sperm and the resulting embryo is carefully monitored as it grows. Fresh embryo transfer allows for a shorter time between egg retrieval and transfer into the uterus, increasing the chances of conception. </span>

<span style="font-weight: 400;">However, there are certain situations where a fresh embryo transfer is not recommended. If a patient's progesterone level is high, it can negatively impact the implantation of the embryo, making a fresh embryo transfer unsuitable. Similarly, if a patient is at risk of hyperstimulation from the medications used to stimulate egg maturation, a fresh transfer could pose a danger to the patient.</span>

<b>Frozen embryo transfers:</b>

<span style="font-weight: 400;">A frozen embryo transfer typically takes place around 6-8 weeks after the embryo has been frozen. When the patient is ready for the transfer, she will be given medications to simulate a natural menstrual cycle. The FET date is then coordinated with the cycle to improve the chances of successful implantation.</span>

<span style="font-weight: 400;">If a patient wants to have her embryos tested for genetic abnormalities, a FET becomes necessary. Preimplantation genetic testing (PGT) is conducted shortly after the retrieval of eggs. A small sample is taken from the embryo for biopsy, and this sample is evaluated for any chromosomal or genetic abnormalities. Once PGT is completed, the embryologist will select only the embryos that are chromosomally normal for transfer. This selective approach significantly increases the likelihood of a successful pregnancy.</span>

<span style="font-weight: 400;">Frozen embryo transfers can also be utilized for future pregnancies even years later, as embryos can be stored indefinitely. Similarly, if a patient wishes to preserve her fertility due to age, cancer treatment, or other reasons, embryos can be created and stored for later use. When the time is right, a FET can be performed.</span>
<h3 style="width: 100%;"><b>The benefits and drawbacks of fresh and frozen embryo transfers</b></h3>
<img class="alignnone size-full wp-image-1142" src="https://www.nufertility.com/blog/wp-content/uploads/2024/02/3-min.jpg" alt="Embryo Transfer in Bangalore - NU Fertility" width="804" height="536" />

<b>Advantages of fresh embryo transfer</b>
<ul>
 	<li><span style="font-weight: 400;">The waiting time for fresh embryo transfer is shorter as embryos are transferred soon after fertilization.</span></li>
 	<li><span style="font-weight: 400;">The embryo is not subjected to the stress of freezing and thawing.</span></li>
 	<li><span style="font-weight: 400;">Fresh cycles involve the process of ovarian stimulation, which can result in a receptive endometrial lining, if the woman is not a hyper-responder. This, in turn, may enhance the chances of a successful embryo transfer.</span></li>
</ul>
<b>Disadvantages of fresh embryo transfer</b>
<ul>
 	<li><span style="font-weight: 400;">Ovarian stimulation during fresh cycles may result in OHSS [Ovarian Hyperstimulation Syndrome], a potentially serious condition marked by enlarged and painful ovaries.</span></li>
 	<li><span style="font-weight: 400;">Due to increased fertility medicines and extra hormones, the presence of higher-than-normal hormone levels in a patient's system can pose challenges for implantation when using their eggs.</span></li>
 	<li><span style="font-weight: 400;">Fresh transfers are time-critical and need to be synchronized with the natural menstrual cycle, providing limited flexibility in terms of timing.</span></li>
</ul>
<span style="font-weight: 400;"> </span><b>Advantages of frozen embryo transfer</b>
<ul>
 	<li><span style="font-weight: 400;">FET provides couples who have encountered challenging situations like cancer treatments with the opportunity to have children once their treatments are successfully completed.</span></li>
 	<li><span style="font-weight: 400;">Women can plan pregnancy when they are ready for it. It provides flexibility in relation to planning the timing of embryo transfer</span></li>
 	<li><span style="font-weight: 400;">Reduced risk of Ovarian hyperstimulation syndrome.</span></li>
</ul>
<b>Disadvantages of frozen embryo transfer</b>
<ul>
 	<li><span style="font-weight: 400;">Not every embryo can withstand the freezing and thawing process, which could lead to a reduced number of embryos available for transfer.</span></li>
 	<li><span style="font-weight: 400;">Going through frozen embryo transfer can be quite time-consuming.</span></li>
</ul>
<b> </b><b>Factors to consider when deciding between fresh or frozen embryo transfer</b>
<ol>
 	<li><b>Personal Health:</b><span style="font-weight: 400;"> If you have any health concerns, such as being at risk of OHSS, opting for frozen embryo transfer could be a safer choice for you.</span></li>
 	<li><b>Timing and Flexibility:</b><span style="font-weight: 400;"> Consider your own schedule, work obligations, and emotional preparedness for starting a family.</span></li>
 	<li><b>Success Rates:</b><span style="font-weight: 400;"> The success rates for both approaches are quite similar, but there are several factors that can influence the outcome, such as age, embryo quality, and medical history.</span></li>
</ol>
<span style="font-weight: 400;"> </span><span style="font-weight: 400;">The price range for </span><a href="https://www.nufertility.com/embryo-transfer"><span style="font-weight: 400;">embryo freezing in Bangalore</span></a><span style="font-weight: 400;"> is typically between Rs.20,000 and Rs.40,000. However, it is important to note that this pricing may vary across different hospitals and clinics. The decision to opt for fresh or frozen embryo transfer is a significant step in your fertility journey. It is important to consult your fertility specialist who can carefully assess your specific circumstances and help you determine the most suitable choice.</span> <span style="font-weight: 400;">Keep in mind that there isn't a one-size-fits-all solution, and your choice should align with your medical needs, emotional well-being, and your ultimate goal of starting a family. With the assistance of your healthcare team, you can make an informed decision for your path to parenthood.</span>

<a href="https://www.nufertility.com/"><span style="font-weight: 400;">NU Fertility in Bangalore</span></a><span style="font-weight: 400;"> provides advanced </span><a href="https://www.nufertility.com/fertility-preservation"><span style="font-weight: 400;">fertility preservation</span></a><span style="font-weight: 400;"> methods. Their dedicated healthcare team ensures exceptional care with precision and expertise in reproductive health. For specialized assistance with embryo transfer, reach out to NU Fertility.</span>

<b>References:</b>
<ol>
 	<li><span style="font-weight: 400;"> Fresh and Frozen Embryo Transfers. Society For Assisted Reproductive Technology. https://www.sart.org/patients/fyi-videos/fresh-and-frozen-embryo-transfers/.</span></li>
 	<li><span style="font-weight: 400;"> For Women Undergoing IVF, Is Fresh or Frozen Embryo Transfer Best? https://corporate.dukehealth.org/news/women-undergoing-ivf-fresh-or-frozen-embryo-transfer-best.</span></li>
 	<li><span style="font-weight: 400;"> Wong, K. M., van Wely, M., et al. (2017). Fresh versus frozen embryo transfers in assisted reproduction. The Cochrane database of systematic reviews, 3(3), CD011184. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011184.pub2/full.</span></li>
 	<li><span style="font-weight: 400;"> Evans, J., Hannan, N. J., et al. (2014). Fresh versus frozen embryo transfer: backing clinical decisions with scientific and clinical evidence. Human reproduction update, 20(6), 808â821. https://academic.oup.com/humupd/article/20/6/808/2952620?login=false.</span></li>
</ol>
<span style="font-weight: 400;">Author: </span><a href="https://www.nufertility.com/dr-sneha-j"><span style="font-weight: 400;">Dr. Sneha J</span></a>
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